ABSTRACT:

Cancer is an age old disease which has claimed millions of human lives along with other fatal diseases . Cancer of the cervix is the most prevalent form of cancer in developing countries especially the South -East Asia region The present study is undertaken to determine the efficacy of the crystallisation test for the detection of malignancy in cancer cases of the female genital tract and also to determine the efficacy of this test to detect the precancerous conditions ( Erosion of cervix etc.) of the female genital tract and to know whether the results of crystallisation test correlate with the histopathological diagnosis of cancer and precancerous cases. Crystallisation test was carried out in 300 female patients from Gynaecology wards of Government Medical College and Hospital, Aurangabad. Out of 300 cases studied ,211 cases were diagnosed cancer patients , 39 cases were in precancerous stage and 50 were non-cancer cases. The non-cancer cases, including 10 normal cases were taken as a control. Out of 211 diagnosed cancer cases,92 were histologicaly proved cancer case. Positive results were obtained in 94.7% cases of malignancy. Positive results were obtained into 84.6% of precancerous cases. To all the cancer and non-cancer cases of the female genital tract, Chi-Square test was applied, degree of freedom was calculated and the significance of the test i.e. P value was calculated P value was found to be far less than 0.001 .This indicates that the crystallization test is statistically highly significant test for the detection of malignancy.

Keywords: Crystallization , malignancy , precancerous.