ABSTRACT:

Background and objective: The study was undertaken with the objective to find out the distribution of ABO blood groups, gene frequency and genotype frequency in population of Khammam.

Materials and Methods: The study group includes a total of 15846 blood donors from Khammam. The study was a retrospective study, all donors were registered in the central blood bank at Mamata Medical College during the period of last five years.

Results: The study showed that O is the most common blood group (43.21%) followed by B (30.50%), and then A at (20.38%) while AB is the least prevalent group at (05.91%). The gene frequencies were calculated by using Fisher’s maximum likelihood method modified by Dobson and Ikin, the genotype frequency is calculated by using Hardy–Weinberg principle. The calculated gene frequencies are A 0.140, B 0.202, O0.658; O > B > A.

Conclusion: The study provides information about the distribution of blood group in general population of Khammam and that O is prevailing; gene frequency of O is 0.658. This knowledge may help us to safeguard against the diseases that are likely to influence O gene.

Keywords: gene frequencies, general population.

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